血管氨酸转化酶基因InDel多态和COVID-19疾病之间存在强烈的联系
Havva Çobanogullari1,2, Emine Unal Evren3,2, Hakan Evren3,2
1Department of Molecular Medicine, Institute of Graduate Studies, Near East University, Nicosia, Cyprus.
概括
ангиотензин转化酶 (ACE) I/D 多态可能预测COVID-19的严重程度. 特定的ACE基因型与COVID-19风险增加,症状呈现以及症状发作和治疗持续时间的差异有关.
科学领域:
- 遗传学 是一个遗传学.
- 流行病学 流行病学
- 分子生物学分子生物学
背景情况:
- 源自2019年底的COVID-19大流行,已经对全球产生了影响.
- 宿主遗传变异可能会影响COVID-19的易感性和严重程度.
- ангиотензин转化酶 (ACE) 基因I/D多态化是对COVID-19遗传影响的候选者.
研究的目的:
- 调查北塞浦路斯ACE I/D多态和COVID-19之间的关联.
- 为了确定ACE基因型是否影响COVID-19风险和临床表现.
主要方法:
- 一项涉及250名COVID-19患者和371名健康对照者的病例控制研究.
- 使用聚合酶链反应 (PCR) 进行了ACE I/D多态的基因定型.
主要成果:
- 与对照人群相比,COVID-19患者中ACE DD同位素的发生频率明显高 (p=0.022).
- 患者中D等位基因的流行率 (57.2%) 比对照组 (50.67%,p<0.05) 更高.
- 具有II基因型的个体患有COVID-19症状的风险更高 (p=0.011).
- 与其他基因型相比,DD基因型与更频繁的胸部放射性发现 (p=0.005),更短的症状发作 (p=0.016) 和更长的治疗持续时间 (p=0.014) 相关.
结论:
- ACE I/D 多态性是 COVID-19 严重程度的潜在预测因素.
- 特定的ACE基因型与COVID-19的差异性风险,临床表现和疾病进展有关.
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