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内分泌,FGF2和PDGF表达与垂体神经内分泌瘤 (PitNET) 侵袭性的关联

Pengyu Tao¹, Xiaofeng Liu, Qiuhang Zhang

¹Xuanwu Hospital, Capital Medical University, Department of Otorhinolaryngology Head and Neck Surgery, Beijing, China.

Turkish neurosurgery

|June 13, 2023

概括

侵袭性垂体瘤显示高Endocan和FGF2水平,PDGF低. 这些血管生成因子,Endocan和FGF2,可能为垂体神经内分泌瘤 (PitNETs) 提供新的治疗点.

科学领域:

内分泌学在内分泌学.
在瘤学瘤学.
分子生物学分子生物学

背景情况:

下垂体神经内分泌瘤 (PitNETs) 可能是侵入性的,复杂化手术并增加复发风险.
洞穴鼻腔侵入是PitNET管理中的一个重大挑战.
识别与侵入性相关的分子标记物对于向治疗至关重要.

研究的目的:

调查血管新生因素 (Endocan,FGF2,PDGF) 与PitNETs的侵入性之间的关联.
探索这些因素作为侵入性PitNET的治疗点的潜力.

主要方法:

量化实时PCR (qRT-PCR) 用于测量29个人类PitNET标本中的Endocan mRNA表达.
其他血管性标记物FGF-2和PDGF的基因表达也使用qRT-PCR进行了评估.
分析了包括PitNET血统,性别,年龄和成像数据在内的临床参数.

主要成果:

内分泌表达与PitNET侵入性正相关.
具有高Endocan表达的标本显示FGF2水平升高.
在FGF2和PDGF表达之间观察到负相关性.

结论:

在垂体瘤发生过程中,Endocan,FGF2和PDGF之间存在复杂的相互作用.
升高的Endocan和FGF2,加上低的PDGF,是侵入性PitNETs的特征.
恩多坎和FGF2代表了入侵性PitNET的有希望的新型治疗点.

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