头部和多器官创伤患者的氧化应激和生化变化
Yener Akyuva1, Gokhan Nur, Haci Ahmet Deveci
1Hatay Mustafa Kemal University, Tayfur Ata Sökmen Faculty of Medicine, Department of Neurosurgery, Hatay, Turkey.
Turkish neurosurgery
|June 13, 2023
概括
氧化应激标志物如偏氧酶 (PON),总抗氧化剂状态 (TAS) 和总氧化剂状态 (TOS) 在创伤患者中发生显著变化. 这些生化标志物有助于监测重症监护患者和评估创伤反应.
科学领域:
- 生物化学 生物化学
- 创伤医学 创伤医学
- 关键的护理关键的护理
背景情况:
- 头部和多个器官的创伤引发显著的生理压力.
- 氧化应激在创伤的病理生理学中起着至关重要的作用.
- 监测生化标志物对于管理创伤患者至关重要.
研究的目的:
- 在创伤患者中评估偏氧酶 (PON),总抗氧化剂状态 (TAS),总氧化剂状态 (TOS),高密度脂蛋白 (HDL),CRP,AST,ALT,GGT和ALP水平.
- 评估创伤后这些标记物的动态变化.
- 探索这些标志物与临床结果之间的相关性.
主要方法:
- 这项研究包括29名头部和多器官创伤的男性患者.
- 在创伤后的第1,3天和第7天分析了血液样本.
- 测量了PON,TAS,TOS,HDL,CRP,AST,ALT,GGT和ALP的水平,这些水平都被测量了.
主要成果:
- 偏氧酶 (PON),总抗氧化剂状态 (TAS),总氧化剂状态 (TOS) 和C反应蛋白 (CRP) 水平在创伤后的第1天和第3/7天之间显示出统计学上显著的差异.
- 高密度脂蛋白 (HDL) 水平没有显示显著变化.
- 在CRP和AST/ALT/GGT之间发现了中度的正相关性,在CRP和ALP之间发现了中度的负相关性.
结论:
- 在创伤患者中,氧化应激参数 (PON,TAS,TOS) 显著改变.
- 生物化学标志物,包括氧化应激指标,对于预后和监测重症监护患者是有价值的.
- 这些标志物为患者对创伤和治疗的反应提供了洞察力.
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