现实世界治疗强度和近视冠状动脉新血管化患者的模式:眼科医学的常见数据模型
Manh-Hung Bui1,2, Da Yun Lee2, Sang Jun Park1,3
1Department of Ophthalmology, College of Medicine, Seoul National University, Seoul, Korea.
Journal of Korean medical science
|June 13, 2023
概括
现实数据显示,抗血管内皮生长因子 (VEGF) 药物是近视性冠状腺新血管化 (mCNV) 的主要治疗方法. 在第一年后,治疗强度显著下降,大多数患者接受单一治疗.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 有限的现实世界数据存在于对近视性冠状腺新血管化 (mCNV) 的抗血管内皮生长因子 (VEGF) 药物治疗.
- 调查现实世界的治疗强度和模式对于了解当前mCNV管理至关重要.
研究的目的:
- 在抗VEGF治疗时代,分析近视性胆道新血管化 (mCNV) 的现实治疗强度和模式.
- 评估mCNV患者治疗频率和药物选择的趋势.
主要方法:
- 使用观察医学结果伙伴关系-共同数据模型数据库进行回顾性观察性研究.
- 从2003年至2020年对未接受过治疗的mCNV患者的分析,重点关注治疗强度和模式.
- 结果包括处方趋势,平均每年注射量和治疗转换行为.
主要成果:
- 96.8%的患者使用抗VEGF药物,主要是贝瓦齐祖马布,作为第一线治疗.
- 与第一年 (2.09) 相比,第二年 (0.47) 观察到平均注射量的下降趋势.
- 大多数患者 (86.2%) 接受了不切换单一治疗,贝瓦齐祖马布是最常见的选择.
结论:
- 抗VEGF药物是对mCNV的既定选择治疗和二线治疗.
- 非切换单一治疗是主要的治疗方案,突出显示了初始抗VEGF治疗的有效性.
- 在开始治疗后的第二年,治疗频率显著下降.
相关概念视频
Open Angle Glaucoma: Treatment
491
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
491
Angle Closure Glaucoma: Treatment
578
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
578
Glaucoma: Overview
633
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
633


