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亚洛克1254对大鼠肝脏的毒性作用和修改的作用

Aylin Balcı Özyurt^1,2, Pınar Erkekoğlu¹, Naciye Dilara Zeybek³

¹Department of Toxicology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.

International journal of environmental health research

|June 13, 2023

概括

多双 (PCB) 会导致肝损伤,氧化应激和亡. 缺乏会加剧这些影响,而补充剂提供了对Aroclor 1254毒性的部分保护.

科学领域:

环境毒理学环境毒理学
肝病学肝病学是一种肝病学.
营养生物化学营养生物化学

背景情况:

多双 (PCB) 是有毒的工业化学品,对环境造成广泛污染.
亚洛克1254 (A1254),一种商业PCB同源,具有肝毒性,代谢和内分泌疾病的风险.
了解PCB暴露与等营养因素之间的相互作用对于公共卫生至关重要.

研究的目的:

在雄性大鼠中研究Aroclor 1254 (A1254) 的肝毒性作用.
为了评估缺乏和补充对A1254引起的肝损伤的影响.
评估氧化应激和亡在PCB毒性的作用.

主要方法:

在5周的时间里,老鼠被食了具有不同水平 (缺乏,控制,补充) 的饮食.
在养期的最后15天内,A1254被口服给特定群体.
对肝脏组织进行了分析,以检测其病理学变化,氧化剂/抗氧化剂平衡,细胞亡和细胞循环蛋白 (p53,p21).

主要成果:

A1254暴露诱导肝脏组织学显著变化,表明肝毒性.
暴露于PCB导致氧化剂/抗氧化剂状态的不平衡,表明氧化应激.
缺乏症加剧了氧化应激和亡,而补充剂显示出对A1254毒性的部分保护作用.

结论:

亚洛克1254通过涉及氧化应激和亡的机制引起肝损伤.
状态显著调节对PCB诱导的肝毒性反应.
进一步的体内机制研究是有必要的,以充分阐明PCB的肝毒性和的保护作用.

关键词:

聚化双烯的多种类型灭症 (apoptosis) 是一种死亡的过程.肝脏肝脏肝脏肝脏肝脏肝脏氧化应激是一种氧化应激.是一种.

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