一个叙述性审查的社会经济负担,与一般性性牛皮相关的
Thomas M Zimmermann1, Patrick Hofmann1, Gretchen R Chiu2
1TA Inflammation, Dermatology, Boehringer Ingelheim International GmbH, Ingelheim, Germany.
Experimental dermatology
|June 13, 2023
概括
一般性性牛皮 (GPP) 严重影响患者和医疗保健系统,导致严重并发症,高住院率和成本增加. 这凸显了对有效的GPP特异性治疗的迫切需要.
科学领域:
- 皮肤病学 皮肤病学
- 公共卫生 公共卫生
- 卫生经济学 卫生经济学
背景情况:
- 泛性性牛皮 (GPP) 是一种罕见的,严重的,慢性炎症性皮肤病.
- 最近GPP火焰处理批准强调了需要了解其社会经济负担的必要性.
研究的目的:
- 审查有关患者负担,医疗保健资源利用率 (HCRU) 和与GPP相关的成本的现有证据.
- 为了比较GPP与斑块性牛皮 (PsO) 的负担.
主要方法:
- 对报告GPP患者负担,HCRU和成本的研究文献综述.
- 对GPP患者数据与PsO患者数据进行比较分析.
主要成果:
- GPP患者出现严重并发症 (败血症,心肺衰竭),导致住院和重症监护率高.
- 与PsO患者相比,GPP患者的并发症得分更高,生活质量更差,症状负担增加 (疼痛,,疲劳,焦虑,抑郁),直接医疗费用显著增加.
- GPP通过劳动生产率下降和与医疗相关的缺勤造成了相当大的间接经济负担.
结论:
- 目前的GPP管理与非特异性疗法导致患者和经济负担显著.
- 与GPP相关的高社会经济负担强调了对新,有效的GPP特异性治疗的迫切需要.
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