长时间的T细胞激活和长期的COVID症状独立地与3个月后的严重COVID-19有关
Marianna Santopaolo1, Michaela Gregorova1, Fergus Hamilton2
1School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom.
eLife
|June 13, 2023
概括
严重的COVID-19患者在住院后几个月表现出持续的免疫激活. 这种持续的免疫反应可能与严重的疾病有关,不一定是长期的COVID症状.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 后COVID条件 后COVID条件
背景情况:
- 冠状病毒疾病-19 (COVID-19) 可能导致长期免疫系统障碍和持续的症状.
- 了解COVID-19的长期免疫后果对于管理后急性后果至关重要.
研究的目的:
- 在COVID-19住院后3-12个月的患者中评估免疫激活标记.
- 调查持续免疫激活和长期COVID症状之间的关联.
- 为了比较疾病严重程度 (轻度,中度,严重) 的免疫特征.
主要方法:
- 分析了来自63名住院患有轻度,中度或重度COVID-19的患者的187个样本.
- 评估T细胞激活标记物 (HLA-DR,CD38,Ki67,大酶B) 和血细胞因子水平 (IL-4,IL-7,IL-17,TNF-α).
- 在体外测试重症患者血的健康捐赠者T细胞,以评估对IL-15的反应.
主要成果:
- 患有严重COVID-19的患者在入院3个月后表现出持续的CD4+和CD8+T细胞激活.
- 与轻度/中度病例相比,在严重病例中观察到IL-4,IL-7,IL-17和TNF-α的血水平升高.
- 来自重症患者的血诱导了对健康T细胞的IL-15Rα上调,这表明了增强的旁观者激活潜力.
- 虽然严重的患者报告了更长时间的COVID症状,但这些症状在调整共变量后与免疫激活标志物无关.
结论:
- 持续的免疫激活,特别是T细胞激活和特定的细胞因子概况,与严重的COVID-19疾病有关.
- 严重患者的长期COVID症状与测量的免疫激活标志物没有直接相关.
- 严重的疾病可以独立地驱动持续的免疫激活和长期的COVID症状.
关键词:
这是RBD抗体.在SARS-CoV-2记忆T细胞中.这些T细胞是T细胞.旁观者T细胞激活活动人类 人类 人类 人类 人类 人类 人类免疫学 免疫学 免疫学这是一种炎症炎症炎症炎症.长时间的COVID.有助于炎症的细胞因子.更多相关视频
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