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Updated: Jul 26, 2025

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(±) - 伊博加明的克拉姆级总合成

Alexander J Hughes1, Steven D Townsend1

  • 1Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.

Organic letters
|June 13, 2023
PubMed
概括

本研究介绍了 (±) - 伊波加胺在仅9个步骤中的全克级合成. 这种高效的方法实现了24%的总产量,为伊波加胺生产建立了新的途径.

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Preparation of 1° Amines: Gabriel Synthesis01:28

Preparation of 1° Amines: Gabriel Synthesis

Direct alkylation is not a suitable method for synthesizing amines because it produces polyalkylated products. Gabriel synthesis is the most preferred method to exclusively make primary amines. The method uses phthalimide, which contains a protected form of nitrogen that participates in alkylation only once to predominantly give primary amines.
Strong bases like NaOH or KOH deprotonate the phthalimide to form the corresponding anion, which acts as a nucleophile. Further, the anion attacks an...
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