季节性人类冠状病毒的不断演变和新兴血统:一个多中心监测研究
Run-Ze Ye1, Cheng Gong2, Xiao-Ming Cui3,4
1Institute of EcoHealth, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Journal of medical virology
|June 13, 2023
概括
在北京,季节性人类冠状病毒 (HCoV) 感染了2.0%的呼吸道疾病患者. 分析显示正在进行的进化和负选择,表明未来变异的潜力.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 基因组学就是基因组学.
背景情况:
- 季节性人类冠状病毒 (HCoV) 是具有动物源的重要呼吸道病原体.
- 了解它们的流行病学和进化动态对于公共卫生至关重要.
研究的目的:
- 在北京的急性呼吸道疾病患者中调查HCoVs的流行病学和进化特征.
- 确定流行的HCoV类型并分析它们的遗传多样性和进化压力.
主要方法:
- 在2016-2019年期间,对类似流感的疾病 (ILI) 和严重急性呼吸道感染 (SARI) 患者的多中心监测.
- 多重复合实时RT-PCR用于HCoV查和全基因组分析的转基因组测序.
- 遗传学和进化分析,包括选择压力评估.
主要成果:
- 在15677名患者中,HCoV被检测到2.0%;HCoV-OC43 (40.5%) 和HCoV-NL63 (38.3%) 是最常见的.
- 严重急性呼吸道感染 (SARI) 病例较老,更频繁地与HCoV-229E和HCoV-OC43相关,同时感染率更高.
- 遗传学分析发现了HCoV-229E,HCoV-NL63和HCoV-OC43的新型血统,所有这些都处于负选择压力之下.
结论:
- 人类冠状病毒是呼吸系统疾病的重要原因,随着不断的进化和新血统的出现.
- 加强监测是必要的,以监测HCoV流行病学和预测潜在的未来变种.
- 了解进化模式,特别是尖端糖蛋白,是预测病毒行为的关键.
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