异常的静止状态在强迫症中大规模网络中的有效连接性
Yinhuan Xu1, Shaoqiang Han1, Yarui Wei1
1Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory for Functional Magnetic Resonance Imaging of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China and Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
强迫症 (OCD) 涉及到异常的大脑网络连接. 这项研究发现强迫症患者的关键大脑网络内部和之间的连接中断,与症状严重程度相关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 计算精神病学是一种计算精神病学.
背景情况:
- 强迫症 (OCD) 是一种慢性精神疾病,其特征在于大脑分布区域的功能连接异常.
- 以前的研究主要探讨了非定向的功能连接,网络层面的视角有限.
研究的目的:
- 在大量强迫症患者和健康对照群中调查网络之间的和网络内部的有效连接 (EC).
- 为了确定强迫症中大规模大脑网络相互作用的差异.
- 探索大脑连接模式与强迫症症状严重程度之间的关系.
主要方法:
- 在100名强迫症患者和120名健康对照中使用光谱动态因果建模来评估EC.
- 专注于默认模式 (DMN) 中的八个关键区域,突出 (SN),前端对面 (FPN) 和小脑网络.
- 采用参数实证贝叶斯 (PEB) 框架来检测群体差异,并与耶鲁-布朗强迫性强迫性量表 (Y-BOCS) 分数相关联.
主要成果:
- 观察到强迫症患者和对照人群之间的静止状态网络间和网络内部连接模式的相似之处.
- 在强迫症患者中确定了从左前侧胰岛 (LAI) 到中部前额皮质的增加的EC,以及从右前侧胰岛 (RAI) 到左后侧前额皮质 (L-DLPFC) 的增加.
- 发现从LAI降低到L-DLPFC,RAI降低到前带带皮层 (ACC),以及改变右背侧前额皮层 (R-DLPFC) 的自我连接.
- 观察到ACC-小脑前叶 (CA) 连接和Y-BOCS得分之间的正相关性,以及L-DLPFC-后带皮层 (PCC) 连接和Y-BOCS得分之间的正相关性.
结论:
- 在强迫症中,DMN,SN,FPN和小脑之间存在失调.
- 这四个网络在以目标为导向的行为上下控制中发挥着至关重要的作用.
- 这些网络中的自上而下的干扰可能是强迫症病理生理学和临床表现的基础.
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