药物使用障碍和自杀行为之间的共同遗传和环境病因
Alexis C Edwards1, Henrik Ohlsson2, Séverine Lannoy1
1Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Psychological medicine
|June 13, 2023
概括
共享的遗传和环境因素将物质使用障碍 (SUD) 与自杀行为联系起来. 了解这些联系对于制定联合预防和干预策略对于酒精使用障碍 (AUD) 和药物使用障碍 (DUD) 至关重要.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 药物使用障碍 (SUD) 与自杀行为有显著的关联.
- 在这种共同疾病中,遗传和环境因素之间的相互作用需要进一步的实证研究.
研究的目的:
- 量化共享的遗传和环境因素对酒精使用障碍 (AUD) 或药物使用障碍 (DUD) 与自杀行为 (试图和死亡) 之间的关联有多大影响.
主要方法:
- 采用瑞典国家登记处数据,对一个大型双胞胎和兄弟姐妹队列进行了分析 (N = 1,314,990).
- 采用双胞胎兄弟模型来估计AUD/DUD和自杀企图 (SA) 或自杀死亡 (SD) 之间的遗传和环境相关性.
主要成果:
- 在SA和SUD之间发现了大量的遗传相关性 (rA = 0.60-0.88).
- 共享的环境因素 (rC = 0.42-0.89) 也有所贡献,具有独特的环境因素 (rE = 0.42-0.57).
- 对自杀死亡 (SD) 观察到类似的相关性,共享环境影响更高 (rC = 0.92-1.00).
结论:
- 共享的遗传和独特的环境因素是自杀行为和SUD的共同病态的基础.
- 每种情况都应该被视为对其他情况的风险指标.
- 联合预防和干预策略可能是可行的,尽管这些结果的多基因性质.
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