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在大型fMRI样本中,施用催产素和压缩剂对心态化的无效结果:来自随机对照试验的证据

Mark A Straccia¹, Adam R Teed², Perri L Katzman³

¹Department of Psychology, University of California, Los Angeles, CA, USA.

Psychological medicine

|June 13, 2023

概括

催产素和血管压素并没有改善健康成年人的社会认知或思维能力. 这些发现表明,这些神经对社会处理的作用有限.

科学领域:

神经科学是一个神经科学.
心理药理学心理药理学
社会认知研究社会认知研究

背景情况:

催产素 (OT),血管压素 (AVP) 和社会认知之间存在理论上的联系.
以前的研究经常使用全男性样本,并显示出对心态化的不一致影响.
了解OT和AVP对心智化的影响对于潜在的社会认知治疗至关重要.

研究的目的:

研究催产素和血管压素对健康个体精神化的影响.
在神经类药物注射后进行精神化任务时评估行为和神经反应.

主要方法:

一项随机,双盲,安慰剂控制的研究与186名健康参与者进行.
参与者接受了催产素,血管压素或安慰剂.
测量了心理任务中的行为表现 (反应时间,准确性) 和神经活动.

主要成果:

与安慰剂相比,氧化和压缩的使用都没有影响任务反应时间或准确性.
没有观察到全脑神经激活或功能连接的显著差异.
对调节变量 (同情心,alexithymia) 的探索性分析没有产生显著的相互作用效应.

结论:

鼻内催产素和血管压素在行为和神经水平上对社会认知产生了有限的影响.
这些发现有助于越来越多的证据质疑这些神经对社会处理的广泛有效性.
已注册的临床试验:NCT02393443;NCT02393456;NCT02394054. 已注册的临床试验:NCT02393443;NCT02393456;NCT02394054. 已注册的临床试验:NCT02393443;NCT02393456;NCT02394054. 已经注册的临床试验:NCT02394054. 已经注册的临床试验:NCT02393443;NCT02393456 已经注册的临床试验:NCT02394054.

关键词:

功能磁力共振成像 (fMRI) 是一种功能共振成像.功能连接性的功能连接性这是一种精神化的思维.催产素是一种催产素.思想的思想理论的理论.血管压力中的血管压力.

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