情绪障碍患者未受影响的一级亲属的情绪认知子组
Hanne Lie Kjærstad1, Cristina Varo2, Iselin Meluken1
1Mental Health Services, Capital Region of Denmark, Copenhagen Affective Disorder Research Centre (CADIC), Psychiatric Centre Copenhagen, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Psychological medicine
|June 13, 2023
概括
大型抑郁症 (MDD) 和双相情感障碍 (BD) 患者的健康亲属表现出不同的情感认知概况. 一个个个个个个的.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
背景情况:
- 患有严重抑郁症 (MDD) 或双相情感障碍 (BD) 的患者经常经历情绪认知困难,即使在缓解期间.
- 在这些情绪障碍患者的未受影响亲属中观察到异常的情绪认知,但研究结果不一致.
- 研究未受影响亲属之间的情绪认知异质性对于理解家族风险至关重要.
研究的目的:
- 用数据驱动的方法研究患有重度抑郁症 (MDD) 和双相情感障碍 (BD) 患者的未受影响一级亲属的情感认知异质性.
- 在这个有风险的人群中识别独特的情感认知概况.
- 探索这些形状与神经认知,症状和功能特征之间的关系.
主要方法:
- 从两个队列研究中汇集了94名未受影响的亲属 (33名MDD患者;61名BD患者) 和203名健康对照的数据.
- 通过使用社会场景测试,面部表情识别测试和面部点探测测试来评估情感认知.
- 应用分层集群分析来识别亲属中不同的情感认知概况,并将这些集群与对照进行比较.
主要成果:
- 确定了两个不同的不受影响的亲属群体:"情感上保持" (55%) 和"情感上" (45%).
- 与对照人群相比",情绪弱"的亲属表现出较差的神经认知能力,较高的副综合征躁狂症状,较低的教育程度,以及人际功能困难.
- "情感保存"的亲属在这些措施中与对照相比较.
结论:
- 患有MDD和BD的患者的健康一级亲属表现出离散的情绪认知概况.
- 这些已识别的情绪认知集群可能代表具有情绪障碍家族风险的基因上不同的子组.
- 研究结果表明,潜在的情绪认知标记可以用于识别情绪障碍的基因风险较高的个体.
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