白物质,认知和类似精神病的经历在英国生物银行
M J Bosma1, S R Cox2, T Ziermans1
1Department of Psychology, University of Amsterdam, Amsterdam, Netherlands.
Psychological medicine
|June 13, 2023
概括
较低的白质完整性与类似精神病的痛苦经历有关. 处理速度部分介于白质和一般认知能力之间的联系.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 精神病类经历 (PLEs) 是精神分裂症的危险因素,特别是当痛苦时.
- PLEs与改变的白质和认知有关.
- 调查认知在白质-PLEs关系中的调解作用至关重要.
研究的目的:
- 检查认知因素 (g-因子,处理速度) 是否调解白质性质和PLEs之间的关系.
- 探索白质微观结构和PLEs与痛苦之间的关联.
主要方法:
- 在两个大型英国生物库样本 (N=6170,N=19891) 上使用了路径分析.
- 从概率学路谱学得出的全大脑分数异构性 (gFA) 和平均扩散性 (gMD).
- 在子样本中分析了白质网络效率和微观结构的结构连接组数据.
主要成果:
- 认知没有显著调解白质-PLEs关系.
- 较低的gFA与伴有痛苦的PLEs相关 (β = -0.053,p = 0.011).
- 较低的gFA/较高的gMD与较低的g因子相关,部分由处理速度介导 (7-11%介导).
结论:
- 减少的全球白质微观结构与患有困境的PLEs有关.
- 这一发现需要进一步研究从亚临床到临床精神病症状的进展.
- 确认的处理速度作为白质微观结构和g因子之间的中间体.
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