解开胃排空和暴饮暴食之间的联系. 通过病例控制设计,清除饮食障碍
Pamela K Keel1, Lisa A Eckel2, Britny A Hildebrandt3
1Department of Psychology, Florida State University, Tallahassee, FL, USA.
Psychological medicine
|June 13, 2023
概括
延迟胃排空与清洗行为有关,而不是过度饮食. 纠正胃空化的药物可能会使那些清洗的人的肠道问题恶化.
科学领域:
- 胃肠病学 胃肠病学
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
背景情况:
- 在神经性厌食症和神经性嗜食症 (BN) 中观察到延迟胃空化,但不是过度饮食障碍.
- 这表明,低体重或暴饮暴食本身并不能完全解释缓慢的胃机动性.
- 延迟胃空化和自我诱导吐之间的联系可能会为清洗障碍 (PD) 病理生理学提供见解.
研究的目的:
- 为了研究延迟胃空化和排泄行为之间的关联.
- 检查梅托克洛普拉米德对BN,PD和对照女性胃空和胃肠道困扰的影响.
主要方法:
- 招募了95名符合DSM-5标准的BN (净化或非净化),PD或健康对照的女性.
- 胃排空,肠道和主观反应在安慰剂和美托克洛普拉米德条件下的标准化餐后被评估.
- 采用了一种双盲交叉设计.
主要成果:
- 在安慰剂条件下,延迟胃排空与清洗有关,独立于暴饮暴食.
- 梅托克洛普拉米德使胃空化的群体差异正常化,但没有影响胃肠道困扰.
- 药物增加了餐后PYY释放,与胃肠道困扰相关.
结论:
- 延迟胃排空与清洗行为特别相关.
- 针对胃空化的干预措施可能会使排泄的个体的肠道调节失调变得更糟.
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