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Updated: Jul 26, 2025

Monitoring Leucine-Rich Repeat Containing 8 Channel (LRRC8/VRAC) Activity Using Sensitized-Emission Förster Resonance Energy Transfer (SE-FRET)
08:54

Monitoring Leucine-Rich Repeat Containing 8 Channel (LRRC8/VRAC) Activity Using Sensitized-Emission Förster Resonance Energy Transfer (SE-FRET)

Published on: August 9, 2024

466

LRRC8A阴离子通道通过与米奥辛酸酶-rho相互作用蛋白的关联来调节血管反应

Hyehun Choi1, Michael R Miller1, Hong-Ngan Nguyen1

  • 1Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
|June 13, 2023
PubMed
概括

含有8A (LRRC8A) 的氨酸丰富的重复体积调节离子通道 (VRACs) 调节血管光滑肌细胞功能. 删除LRRC8A可以增强血管扩张,并防止TNFα诱导的血管收缩,这表明VRAC是血管疾病的关键标.

关键词:
在 LRRC8A 离子通道中.这是一种炎症炎症炎症炎症.肌酸酸酶与rho相互作用的蛋白质.血管光滑肌肉细胞细胞血管扩张 血管扩张

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