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在骨肌肉中发现与运动和卡路里限制效应相关的新基因

Jae Sook Kang¹, Min Ju Kim¹, Eun-Soo Kwon¹

¹Aging Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea.

|June 13, 2023

概括

卡路里限制 (CR) 和运动可以提高肌肉功能和寿命. 这项研究确定了两种干预措施上调的七种基因,其中IRS2和NR4A1对肌肉发育至关重要,其他基因调节呼吸,提供了对衰老和运动益处的见解.

科学领域:

衰老和长寿研究研究
骨肌肉生理学骨肌肉生理学
分子生物学分子生物学

背景情况:

运动和热量限制 (CR) 可以延长寿命,并改善不同物种的器官功能.
这两种干预措施都对肌功能产生了积极的影响,但潜在的分子机制仍然不清楚.

研究的目的:

识别受CR调节的基因,并在肌肉组织中进行运动.
研究这些已识别的基因在肌肉功能,肌体发生和相关细胞过程中的作用.

主要方法:

分析了来自卡路里限制灵长类动物和运动后人类肌肉的基因表达综合数据集.
利用C2C12小鼠肌细胞来评估基因沉默对肌体发生,线粒体呼吸,自和胰岛素信号传递的影响.

主要成果:

七个转录 (ADAMTS1,CPEB4,EGR2,IRS2,NR4A1,PYGO1,ZBTB43) 被CR和exercise一致上调.
IRS2和NR4A1对肌肉发育至关重要;EGR2,IRS2,NR4A1,PYGO1和ZBTB43调节了线粒体呼吸.
降低CPEB4促进了肌肉缩基因表达和诱导肌管缩,而不会影响自.

结论:

确定了关键基因 (IRS2,NR4A1,EGR2,PYGO1,ZBTB43),这些基因与CR和运动对骨肌肉的有益影响有关.
这些发现为了解肌肉功能,衰老和寿命延长策略提供了新的分子标.

关键词:

卡路里限制卡路里限制运动就是炼身体.胰岛素敏感性胰岛素敏感性线粒体呼吸系统的呼吸过程肌肉缩肌肉缩肌肉缩肌肉发育 (myogenesis) 是一个过程.

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