补充剂的使用和胃癌风险在南方社区队列研究中
Jessica C Goodwin1,2,3, Qichen Wang4,5, Pao-Hwa Lin6
1Department of Population Health Sciences, Duke University, 2424 Erwin Road, Suite 602, Durham, NC, 27705, USA.
Cancer causes & control : CCC
|June 13, 2023
概括
在一项针对主要是黑人成年人的研究中,定期使用补充剂,包括多种维生素,与非心脏胃癌 (NCGC) 的风险降低有关. 这种保护作用在饮食质量较低的个体中更为明显.
科学领域:
- 流行病学 流行病学
- 营养科学 营养科学
- 在瘤学瘤学.
背景情况:
- 胃癌不成比例地影响到美国的少数群体.
- 保护因素的研究,如食补充剂,是有限的.
- 南方社区队列研究 (SCCS) 为研究这些关联提供了一个独特的队列.
研究的目的:
- 检查定期使用补充剂与胃癌风险之间的关联.
- 在SCCS中研究这种关系,主要是黑人参与者的队列.
- 根据补充剂类型和饮食质量来探索降低风险的潜在差异.
主要方法:
- 从84,508名SCCS参与者的数据分析 (2002-2009).
- 基线调查问卷评估了经常摄入维生素或补充剂 (至少每月一次).
- 考克斯的比例危险模型被用来评估与发生胃癌的关联,按组织学和健康饮食指数 (HEI) 分层.
主要成果:
- 47%的参与者报告定期使用补充剂.
- 在定期使用补充剂时,非心脏胃癌 (NCGC) 的风险降低了30% (HR 0.70).
- 在那些HEI得分较低的人中,任何定期补充剂和多维生素使用都显示出NCGC显著降低风险 (HR分别为0.48和0.30).
- 对于心脏胃癌 (CGC) 没有发现显著的关联.
结论:
- 定期使用补充剂,特别是多种维生素,与NCGC风险降低有关.
- 在饮食质量较低的个体中,保护作用似乎更强.
- 这些发现支持进一步的临床试验,研究在胃癌高风险人群中补充剂的使用.
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