相关实验视频

Updated: Jul 26, 2025

Bronchoalveolar Lavage Exosomes in Lipopolysaccharide-induced Septic Lung Injury

Bronchoalveolar Lavage Exosomes in Lipopolysaccharide-induced Septic Lung Injury

Published on: May 21, 2018

细胞外囊泡:与输血相关的急性肺损伤的作用者

Wolfgang M Kuebler^1,2,3, Nishaka William⁴, Martin Post^3,5

¹Institute of Physiology, Charité-Universitätsmedizin, Berlin, Germany.

American journal of physiology. Lung cellular and molecular physiology

|June 13, 2023

概括

细胞外囊泡 (EVs) 涉及严重的呼吸道输血反应,如输血相关的急性肺损伤 (TRALI). 本综述探讨了EV如何为TRALI做出贡献,提供了潜在的诊断和治疗目标.

科学领域:

免疫学免疫学免疫学
血液学血液学血液学
肺部医学肺部医学

背景情况:

呼吸道输血反应,特别是输血相关的急性肺损伤 (TRALI),是致病率和死亡率的主要原因.
特拉利涉及严重的肺炎,和呼吸衰竭,除了支持性护理之外,诊断和治疗选择有限.
目前的理解表明,TRALI是由受体和捐赠因子参与的双击炎症过程引起的.

研究的目的:

审查细胞外囊泡 (EVs) 在中介TRALI中的新兴作用.
探索EVs作为对TRALI进行治疗干预的潜在目标.
评估EV作为TRALI诊断和检测的生物标志物.

主要方法:

关于细胞外囊泡和TRALI的当前研究的文献综述.
分析了EVs对TRALI炎症级联的贡献机制.
评估EVs在TRALI诊断和治疗方面的潜力.

主要成果:

细胞外囊泡 (EVs) 越来越多地被认为是TRALI的第一个和第二个炎症打击中的关键调解者.
有害的EV可以来自各种来源,包括炎症细胞,细菌和储存的血液制品.
电动汽车有可能准肺组织,加剧炎症和损伤.

结论:

细胞外囊泡代表了输血相关急性肺损伤的病原性的一个重要因素.
针对EVs可能为预防或治疗TRALI提供新的治疗策略.
作为早期检测和风险评估的诊断生物标志物,EV有望在易受TRALI治疗的患者中发挥作用.

关键词:

生物标志物生物标志物血液血液血液血液细胞外囊泡细胞外囊泡与输血相关的急性肺损伤.

更多相关视频

Isolation of Extracellular Vesicles from Murine Bronchoalveolar Lavage Fluid Using an Ultrafiltration Centrifugation Technique

Isolation of Extracellular Vesicles from Murine Bronchoalveolar Lavage Fluid Using an Ultrafiltration Centrifugation Technique

Published on: November 9, 2018

Uptake of Fluorescent Labeled Small Extracellular Vesicles In Vitro and in Spinal Cord

Uptake of Fluorescent Labeled Small Extracellular Vesicles In Vitro and in Spinal Cord

Published on: May 23, 2021

相关概念视频

Overview of Exosomes

Overview of Exosomes

Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...

Intralumenal Vesicles and Multivesicular Bodies

Intralumenal Vesicles and Multivesicular Bodies

Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...