在患有转移性结肠直肠癌的患者中使用AVELUMAB
Jason M Redman1, Geraldine O'Sullivan Coyne2, Clay T Reed1
1Center for Immuno-Oncology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
The oncologist
|June 13, 2023
概括
抗PD-L1抗体Avelumab在转移性结直肠癌 (mCRC) 患者中没有显示出客观反应. 这表明阿维卢马布对未经选择的mCRC患者无效,突出显示了针对性免疫疗法的必要性.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 临床试验 临床试验
背景情况:
- 转移性结直肠癌 (mCRC) 的预后不好,目前治疗的生存益处有限.
- 虽然PD-1/PD-L1抑制剂在特定瘤类型 (微卫星不稳定/不匹配修复缺陷) 中有效,但大多数微卫星稳定/不匹配修复熟练的mCRC患者不会受益.
- 这项研究调查了抗PD-L1抗体阿维卢马布在mCRC患者中的疗效.
研究的目的:
- 评估转移性结直肠癌 (mCRC) 患者的阿维卢马布的客观反应率.
- 评估avelumab在未经选择的mCRC患者群体中的安全性和有效性.
主要方法:
- 进行了一项I期,开放标签,剂量升级试验,连续扩大并行组.
- 招募了22名患有可测量的mCRC的患者,他们之前至少接受过一次转移性疾病的全身治疗.
- 患者每隔两周内静脉注射10毫克/千克的阿维卢马布;之前的免疫检查点抑制剂治疗是排除标准.
主要成果:
- 在接受了avelumab治疗的22名参与者中没有观察到客观反应.
- 无进展生存时间的中位数为2.1个月 (95% CI:1.4-5.5个月).
- 报告了五种3级治疗相关的不良事件,包括GGT升高,PRESS,淋巴缺血和无症状的氨酶/脂酶升高.
结论:
- 在未经选择的患有转移性结肠直肠癌 (mCRC) 的患者中,Avelumab没有表现出任何活性.
- 这些发现与之前对类似患者群体中抗PD-1/PD-L1抗体的研究一致.
- 可能需要进一步的研究来确定mCRC患者的特定亚组,这些亚组可以从PD-L1阻塞中受益.
相关概念视频
Drugs for Treatment of Ulcerative Colitis in IBD
179
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
179
Treatment Resistant Cancers
3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
Tumor Immunotherapy
575
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
575
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K


