自主心脏调节功能与儿童和青少年脑震荡后症状改善无关
Lawrence Richer1, William Craig2, Meghan Linsdell3
1Department of Pediatrics, Division of Neurology, University of Alberta, Edmonton, Alberta, Canada.
Journal of neurotrauma
|June 13, 2023
概括
大多数脑震荡的儿童和青少年表现出异常的心脏自主反射,无论他们是否出现持续的脑震荡后症状 (PPCS). 自主功能测试在受伤后4周和12周没有区分PPCS和没有PPCS的人.
科学领域:
- 儿科神经学 儿科神经学
- 自主神经系统研究 自主神经系统研究
- 创伤性脑损伤研究研究
背景情况:
- 持续的脑震荡后症状 (PPCS) 显示出显著的变化.
- 自主功能障碍是PPCS恢复的潜在贡献者和生物标志物.
- 儿科脑震荡中的心脏自主功能需要进一步调查.
研究的目的:
- 评估脑震荡后儿童和青少年的心脏自主反射和自主功能.
- 为了比较那些有和没有持续性脑震荡症状 (PPCS) 的人之间的自主功能.
主要方法:
- 一项病例控制研究涉及被诊断患有脑震荡的儿科患者 (8至<18岁).
- 标准化临床心脏自主反射测试是在受伤后4周和12周进行的.
- 参与者被评估脑震荡症状和自主反应,包括心率变化和头向上倾斜时的血压.
主要成果:
- 在4周后,61%的脑震荡参与者出现了PPCS,报告了疲劳和头痛等症状.
- 大多数参与者 (70-73%) 在4周和12周都表现出异常的自主反应,包括静态心动减速和低血压.
- 在PPCS和非PPCS组之间没有发现心脏自主反射反应的显著差异.
结论:
- 儿童和青少年在4周和12周脑震荡后的心脏自主反射反应经常异常.
- 这些异常可能表明脑震荡后正在进行的自主功能障碍.
- 进行的自主功能测试没有区分具有或没有PPCS的参与者,这表明症状不仅仅是由可测量的自主功能障碍驱动的.
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