老年人COVID-19后急性后果:多器官并发症和死亡率
Eric Yuk Fai Wan1,2,3, Ran Zhang3, Sukriti Mathur3
1Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Journal of travel medicine
|June 13, 2023
概括
感染2019年新冠病毒病 (COVID-19) 的老年人 (年龄≥60岁) 面临多器官并发症和死亡率的长期风险增加. 建议对这种脆弱人群进行症状发展的监测.
科学领域:
- 老年学是一门学科.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 关于2019年新冠病毒病 (COVID-19) 对老年人群的长期健康后果的证据有限.
- 了解这些风险对于管理60岁及以上个人感染后的健康至关重要.
研究的目的:
- 评估COVID-19感染与老年人 (≥60岁) 中多器官并发症和死亡率之间的长期关联.
- 为老年COVID-19幸存者提供有针对性的监测和管理策略的证据.
主要方法:
- 使用来自英国生物银行和香港电子健康记录的数据,采用了队列研究设计.
- 被诊断为COVID-19的老年人与没有COVID-19的对照组相匹配,并随访长达28个月.
- 考克斯回归分析用于评估多器官结局和全因死亡率的风险.
主要成果:
- COVID-19感染与心血管 (例如,中风,心力衰竭),呼吸 (例如,间歇性肺病),神经精神病 (例如,发作) 和 (例如,急性病) 并发症的风险增加显著相关.
- 主要心血管疾病的危险比率在1.2至1.4之间,间歇性肺病的危险比率在UKB和HK队列分别在3.4至4.0之间.
- 在COVID-19的老年人中,观察到所有原因死亡的风险要高得多,英国的危险比率为4.9,香港的危险比率为2.5.
结论:
- 2019年新冠病毒病显著增加了60岁及以上的个人多器官并发症和死亡的长期风险.
- 建议在COVID-19感染后对老年患者进行这些并发症的积极监测.
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