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乙型肝炎发病率的性别差异 - - 一项基于九个高收入国家的国家数据的多年聚合分析
Manfred S Green1, Naama Schwartz1, Victoria Peer1
1School of Public Health, University of Haifa, Haifa, Israel.
PloS one
|June 13, 2023
概括
甲型肝炎病毒 (HAV) 发病率在所有年龄组的男性中都较高. 这表明生物差异,而不仅仅是行为,导致男性感染率更高,特别是在年轻人群中.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 乙型肝炎病毒 (HAV) 发病率的性别差异尚未得到充分证实.
- 这项研究通过汇集来自高收入国家的估计来解决缺乏数据的问题.
研究的目的:
- 调查和量化不同年龄组中基于性别的HAV发病率差异.
- 确定年龄,国家和时间段对这些性别差异的影响.
主要方法:
- 从9个高收入国家收集了6-25年间发生的HAV病例的性别和年龄数据.
- 使用元分析方法计算男性与女性的发病率比率 (IRR) 并将其汇总起来.
- 使用元回归来分析年龄,国家和时间对IRR的影响.
主要成果:
- 在所有年龄组中观察到HAV发病率在男性中持续过多.
- 聚合的IRR (男性:女性) 范围为1.07至1.46,在15-44岁年龄组 (1.46) 中最高.
- 虽然在所有组中都注意到男性的过剩,但最年轻 (<1岁) 和最年长 (65岁以上) 的年龄组的置信区间包括一个.
结论:
- 年轻男性中HAV的过度发病率表明,除了行为之外,生理和生物因素发挥了作用.
- 对于年龄较大的年龄组来说,差异性暴露似乎很重要.
- 这些发现有助于了解HAV和其他感染性疾病的感染机制,其中男性感染率过高.
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