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工程聚乙烯糖醇涂层铁纳米颗粒作为一种新型磁共振成像对比剂

Shadab Dabagh¹, Somayeh Asadi Haris¹, Yavuz Nuri Ertas^1,2

¹ERNAM─Nanotechnology Research and Application Center, Erciyes University, Kayseri 38039, Türkiye.

ACS biomaterials science & engineering

|June 13, 2023

概括

聚乙烯糖醇 (PEG) 涂层可以防止聚合,并增强铁纳米颗粒的生物相容性. 这些涂有PEG的纳米颗粒显示出作为T2重量磁共振成像 (MRI) 的安全有效的对比剂的潜力.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
生物医学工程生物医学工程

背景情况:

通过热水方法合成的铁纳米颗粒 (NP) 经常面临聚合问题.
提高NP生物相容性对于生物医学应用,如磁共振成像 (MRI),至关重要.
用聚乙烯糖醇 (PEG) 进行表面功能化是一种增强NP稳定性和生物相容性的策略.

研究的目的:

为了合成和表征PEG功能化的铁酸盐NP.
评估这些NP作为MRI对比剂的潜力.
评估PEG涂层NP的生物相容性和细胞毒性.

主要方法:

铁酸盐NP的水热合成,然后进行PEG功能化.
使用富里埃变换红外光谱学,能量分散式X射线光谱学和高分辨率传输电子显微镜进行了表征.
使用振动样本磁力计和泽塔电位测量对磁性质的评估.
通过对人类正常皮肤细胞的MTT测定进行细胞毒性评估.
评估MRI对比度增强能力.

主要成果:

合成的NP表现出一个立方螺旋结构,平均尺寸为8nm (TEM: 14nm),PEG涂层后稳定性得到改善.
福利埃变换红外光谱学证实了螺旋铁和PEG波段的形成.
泽塔电位从-24.5mV降至-36.5mV,表明PEGylation成功.
观察到高和磁化 (∼50emu/g),适合生物医学用途.
在人类正常皮肤细胞上,MTT测定显示了PEG涂层NP的可忽略的细胞毒性.
核磁共振扫描显示,PEG@Zn铁素NP是有效的T2加权对比剂.

结论:

PEG功能化有效地防止聚合,并增强铁纳米颗粒的生物相容性.
PEG@Zn铁NP具有出色的磁性和低细胞毒性,使其适合生物医学应用.
这些涂有PEG的NP是T2加权MRI的有前途的对比剂,能够显著提高图像对比度.

关键词:

对比剂是一种对比剂.费里特 (ferrites) 是一种铁矿.磁性纳米粒子是一种磁性纳米粒子.磁共振成像技术的使用放松性放松性

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