在COVID-19肺炎中非HDL胆固醇的预后值
Fatih Sivri1, Mehtap Şencan1, Şerife Barçın Öztürk2
1Dortyol State Hospital, Hatay - Turquia.
在SARS-CoV-2感染之前测量的非高密度脂蛋白胆固醇 (非HDL-C) 是COVID-19患者死亡率的重要预测因素. 较高的非HDL-C水平表明预后较差,建议将其用作预后生物标志物.
科学领域:
- 心血管医学 心血管医学
- 传染性疾病 传染性疾病
- 生物标志物发现发现
背景情况:
- 非高密度脂蛋白胆固醇 (非HDL-C) 是心血管疾病和其他慢性炎症状况的已知预测因素.
- 它的预测潜力扩展到诸如中风,血液透析,移植后并发症,非酒精性肝硬化和艾滋病毒等疾病.
研究的目的:
- 评估感染前非HDL-C水平对COVID-19患者死亡率的预测值.
- 为了确定非HDL-C是否可以作为COVID-19结果的预后生物标志物.
主要方法:
- 一项对2020年1月至2022年6月期间被诊断患有COVID-19肺炎的1435名患者的回顾性研究.
- 通过PCR确认COVID-19诊断;患者分为存活 (723) 和不存活 (712) 组.
- 进行了回归和ROC分析,以评估风险因素和预测准确性.
主要成果:
- 高龄,乳酸脱酶 (LDH),C反应蛋白 (CRP),甘油三,D-二次和非HDL-C的升高是死亡的独立风险因素.
- 非HDL-C在预测死亡率方面显示了61.6%的灵敏度和89.2%的特异性.
- 年龄,CRP和LDH与非HDL-C水平正相关.
结论:
- 感染前非HDL-C水平是COVID-19死亡率的有价值的预后生物标志物.
- 这一发现支持非HDL-C在预测各种炎症和传染性疾病的结果方面更广泛的实用性.
- 进一步的研究可以探索针对脂质资料的治疗策略,以改善COVID-19患者的治疗结果.
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