定义和癌症患病率对支气管镜诊断产量估计的影响:基于模拟的分析
Anil Vachani1, Fabien Maldonado2, Balaji Laxmanan3
1Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Annals of the American Thoracic Society
|June 13, 2023
概括
支气管镜检查的诊断产量 (DY) 计算有很大的差异. 不同的方法来分类非恶性发现和癌症患病率极大地影响DY估计,阻碍研究比较和需要标准化.
科学领域:
- 肺部病理学 肺部病理学
- 医学诊断 医学诊断 医学诊断
- 研究方法研究方法研究方法学
背景情况:
- 支气管镜诊断产量 (DY) 估计因不同的计算方法而有所不同.
- 这种变异性阻碍了跨研究的比较和结果的一致解释.
研究的目的:
- 量化不同计算方法对支气管镜DY估计的影响.
- 确定导致DY计算变化的因素.
主要方法:
- 基于模拟的分析,使用不同的癌症患病率和非恶性发现分类.
- 使用四种不同的方法计算DY,包括对真负数的不同标准.
- 执行场景和概率灵敏度分析,以评估参数的影响.
主要成果:
- 在76.7%的对对方法比较中观察到具有临床意义的DY差异 (>10%).
- 在90%以上的场景中,方法4始终产生更高的DY估计 (>10%).
- 癌症患病率显著影响了DY估计.
结论:
- 非恶性发现的分类和癌症患病率是DY变异性的关键驱动因素.
- 各种方法的实质性变化限制了当前支气管镜学研究的解释性.
- 对于可靠的比较,迫切需要对DY计算方法的标准化.
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