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Updated: Jul 26, 2025

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杜洛特格拉维尔和拉米武丁的临床使用和有效性:长期,现实世界的回顾性研究
Adrián Martínez-Serra1, Elisa De Lazzari1,2,3, Leire Berrocal2
1Infectious Disease Department, School of Medicine, University of Barcelona, Barcelona, Spain.
The Journal of antimicrobial chemotherapy
|June 13, 2023
概括
现实数据显示,在艾滋病毒患者中,多卢特格拉维尔/拉米丁的病毒抑制率很高. 某些子组,包括女性和病毒载量较高的人,在12个月后面临降低有效性的更大风险.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 药理学 药理学是指药理学的学科.
背景情况:
- 临床试验支持杜洛特格拉维尔/拉米丁在艾滋病毒治疗中使用.
- 关于杜洛特格拉维尔/拉米丁有效性的现实数据有限.
研究的目的:
- 评估dolutegravir/lamivudine在真实世界HIV患者群体中的临床使用和有效性.
- 为了确定与治疗有效性相关的因素.
主要方法:
- 回顾性,观察性,单中心研究.
- 包括1049名已经接受过治疗的HIV患者,开始服用多卢特格拉维尔/拉米丁.
- 在6个月和12个月使用在治疗 (OT),修改治疗意图 (mITT) 和治疗意图 (ITT) 分析评估病毒抑制.
主要成果:
- 观察到高病毒抑制率:97% (OT),92% (mITT),81% (ITT) 在6个月和98% (OT),90% (mITT),80% (ITT) 在12个月.
- 女性,先前使用蛋白酶抑制剂 (PI) 和基线病毒载量≥50拷贝/毫升与12个月后缺乏有效性有关.
- 90%的患者继续服用多洛特格拉维尔/拉米丁;毒性是最常见的中止原因 (46%).
结论:
- 多卢特格拉维尔/拉米武丁在现实环境中,在经过治疗的艾滋病毒患者中显示出高的病毒抑制作用.
- 特定的子组需要更密切地监测潜在的缺乏有效性的情况.
- 现实数据证实了多卢特格拉维尔/拉米丁的疗效,同时突出了针对性后续监测的领域.
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