早期出现2型糖尿病的DKD患者的临床和病理特征
Liang Wu1, Yi-Yang Zhao1, Meng-Rui Li1
1Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing 100034, China.
Journal of diabetes and its complications
|June 13, 2023
概括
早期发病的2型糖尿病 (T2DM) 与糖尿病病 (DKD) 患者的更严重的问题有关. 然而,这种早期的T2DM发作并不是DKD中不良结局的独立预测因素.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 糖尿病学 糖尿病学
背景情况:
- 糖尿病病 (DKD) 是2型糖尿病 (T2DM) 的一个主要并发症.
- 早期T2DM对DKD严重程度和患者结局的影响尚不清楚.
- 了解这些关联对于管理DKD进展至关重要.
研究的目的:
- 调查早期T2DM的DKD患者的临床病理学特征.
- 根据T2DM发病年龄,分析DKD患者的结局.
- 确定早期发病的T2DM是否可以独立预测DKD的结局.
主要方法:
- 对489名DKD患者的回顾性分析.
- 分类为早期 (发病年龄<40岁) 和晚期 (发病年龄≥40岁) T2DM发病组.
- 使用考克斯回归分析的临床,组织病理学数据和结局的分析.
主要成果:
- 早期发病的T2DM患者 (n=142) 与晚期发病的患者 (n=347) 相比,表现出更差的血糖控制和更严重的蛋白尿.
- 在早期发病组中观察到更严重的淋巴细胞病变.
- 虽然早期发病的T2DM与无变量分析中的不良事件相关,但在调整混因素后,它不是一个独立的预测因素.
结论:
- 早期出现T2DM的DKD患者表现出更严重的临床病理表现.
- 在T2DM发病时的年龄与估计的淋巴细胞过率 (eGFR) 斜率有显著的相关性.
- 早期T2DM发病与更糟糕的病特征有关,但不是DKD病结局的独立风险因素.
相关概念视频
Diabetes: Symptoms, Diagnosis, and Complications
605
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
605
Chronic Kidney Disease II: Clinical Manifestations
42
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
42
Chronic Kidney Disease I: Introduction
43
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage kidney disease (ESKD). At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate...
43
Pathophysiology of Diabetes
1.0K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.0K
Diabetes Mellitus: Type 2 and Gestational
2.6K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.6K
Diabetes Mellitus: Overview and Type I Subtype
2.8K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.8K


