全血基本微量元素与老年人认知功能之间的关联
Yao-Yao Lin1, Lin Meng1, Fan-Jia Guo2
1Department of Public Health, Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
Ecotoxicology and environmental safety
|June 13, 2023
概括
像这样的必需微量元素 (ETE) 与老年人更好的认知功能有关. 这项研究强调了考虑这些营养素对大脑健康的综合作用的重要性.
科学领域:
- 营养神经科学 营养神经科学
- 老年学是指老年学的学科.
- 环境健康 环境健康
背景情况:
- 基本微量元素 (ETE) 对神经系统的功能至关重要.
- 现有的关于ETE和老年人认知功能的研究是有限的和不确定的.
- 了解这些关联对于维持老年人群的认知健康至关重要.
研究的目的:
- 研究ETE与老年人认知功能之间的个人和联合关联.
- 探索剂量-反应关系,并确定关键的贡献因素.
- 为支持认知健康的潜在营养策略提供证据.
主要方法:
- 研究人口:2181名来自中国义乌群体的老年人 (平均年龄≥65岁).
- 测量:通过ICP-MS分析的全血 (Cr), (Se), (Mn) 和铜 (Cu) 的度.
- 认知评估:迷你心理状态检查 (MMSE),涵盖定向,注册,注意力,计算,回忆和语言.
- 统计分析:线性回归,限制立方线 (RCS) 分析和贝叶斯核机器回归 (BKMR).
主要成果:
- (Cr) 显示出与MMSE分数的非线性,反转的U形关联,特别影响注册表,回忆和语言.
- 增加的 (Se) 水平与整体MMSE得分和所有五个认知领域都有积极的关联.
- 贝叶斯核机器回归表明ETE和认知功能的混合物之间存在正相关性,其中Se是最重要的贡献者.
结论:
- Cr与认知之间的非线性关系表明,可能存在一个最佳度范围.
- 外星体的联合作用与认知功能有积极的关联,强调考虑营养混合物的重要性.
- 需要进一步的前性和干预性研究来证实这些发现,并为临床实践提供信息.
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