肥胖和性别特定的癌症风险
Mathias Rask-Andersen1, Emma Ivansson1, Julia Höglund1
1Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Box 256, 751 05 Uppsala, Sweden.
Cancer cell
|June 13, 2023
概括
肥胖和体脂分布显著影响癌症风险. 这项研究揭示了脂肪积累和分布如何影响男性和女性癌症发展的性别特异性.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 代谢健康 代谢健康
背景情况:
- 肥胖是众所周知的各种癌症的风险因素.
- 脂肪分布模式在两性之间存在显著差异,并且可能独立地影响癌症风险.
- 肥胖对癌症的性别特异性影响仍未得到充分研究.
研究的目的:
- 研究脂肪积累和分布对19种不同类型癌症发病风险的性别特异性影响.
- 为了确定总体脂肪或特定的脂肪分布模式是否会增加癌症风险.
- 为了确定与男性和女性之间的肥胖相关的不同风险的癌症.
主要方法:
- 使用442519名参与者的英国生物库数据进行的前性队列研究.
- 对14种不同的脂肪表型 (脂肪积累和分布) 的分析.
- 考克斯的比例危险模型用于评估与癌症发病率的关联,平均随访时间为13.4年,对显著性的错误发现率为5%.
主要成果:
- 与肥胖相关的特征与研究的19种癌症类型中,除了3种外,与所有癌症类型有关.
- 总体脂肪积累与更广泛的癌症有更强烈的关联,而不是脂肪分布模式.
- 在与脂肪积累或分布有关的结肠直肠,食道和肝癌风险方面观察到明显的性别差异.
结论:
- 肥胖,包括积累和分布,广泛与癌症风险有关.
- 脂肪积累似乎是一个比特定的脂肪分布模式更普遍的癌症风险因素.
- 了解肥胖与癌症的性别相关性对于有针对性的预防和风险评估至关重要,特别是对于结肠直肠,食道和肝癌.
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