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Updated: Jul 26, 2025

Quantifying Replication Stress in Ovarian Cancer Cells Using Single-Stranded DNA Immunofluorescence
06:25

Quantifying Replication Stress in Ovarian Cancer Cells Using Single-Stranded DNA Immunofluorescence

Published on: February 10, 2023

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瘤性IDH突变增加了与异色染色体相关的复制应激,而不会影响同源重组

Juan-Manuel Schvartzman1, Grace Forsyth2, Henry Walch3

  • 1Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA; Department of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY, USA.

Molecular cell
|June 13, 2023
PubMed
概括

瘤性IDH1/2突变产生2HG,增加IDH突变瘤的复制应激. 聚--基) 聚合酶 (PARP) 抑制剂破坏DNA修复,验证PARP作为这些癌症的治疗标.

关键词:
在PARP中,PARP是PARP.二氧化碳基因酶的使用.异性染色是一种异性染色.异酸盐脱基酶是什么在cometabolite上进行代谢.复制压力是复制的压力.

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Quantitation and Analysis of the Formation of HO-Endonuclease Stimulated Chromosomal Translocations by Single-Strand Annealing in Saccharomyces cerevisiae09:40

Quantitation and Analysis of the Formation of HO-Endonuclease Stimulated Chromosomal Translocations by Single-Strand Annealing in Saccharomyces cerevisiae

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