[翻译文章] 在实验室从PMMA骨水泥中化局部麻醉剂
M Monfort-Mira1, M Jornet-Gibert1, C Yela-Verdú2
1Departamento de Cirugía Ortopédica y Traumatología, Hospital Clínic, Barcelona, Spain.
Revista espanola de cirugia ortopedica y traumatologia
|June 13, 2023
概括
聚甲基甲酸盐 (PMMA) 骨在体外有效地消除局部麻醉剂,利多卡因和布皮瓦卡因. 这项研究显示了PMMA骨水泥作为术后疼痛管理药物输送系统的潜力.
科学领域:
- 整形外科手术 整形外科手术
- 生物材料科学 生物材料科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 在全膝关节整形术后最佳的疼痛管理仍然是一个挑战,目前没有黄金标准的药物输送系统.
- 骨水泥,特别是聚甲基甲酸 (PMMA),自20世纪70年代以来一直被用作药物输送系统,主要用于抗生素.
研究的目的:
- 描述两个局部麻醉剂的化特征:利多卡因化和布皮瓦卡因化.
- 评估PMMA骨水泥作为手术后疼痛管理局部药物输送系统的潜力.
主要方法:
- 帕拉科斯® R+G骨头水泥的样本使用利多卡因化或布皮瓦卡因化进行准备.
- 标本被浸入酸盐缓冲盐水 (PBS) 中,并在不同的时间点取样.
- 在PBS中的局部麻醉剂度使用液态染色学量化.
主要成果:
- 从PMMA骨水泥中的利多卡因化达到9.74%在72小时和18.73%在336小时.
- 从PMMA骨水泥中的布皮瓦卡因化量在72小时后为2.71%,在336小时后为2.70%.
- 在72小时内化剂量接近临床麻醉阻塞中使用的剂量.
结论:
- 局部麻醉剂在实验室中证明了PMMA骨的化.
- 在骨科手术中,PMMA骨水泥显示出作为局部麻醉剂的药物输送工具的前景.
- 这项研究支持对PMMA骨质水泥的研究,以改善关节形成术后的疼痛控制.
关键词:
止痛药 止痛药是一种止痛药.关节质整术是指关节质整术.关节增生病 (Artroplastia) 是一种关节增生病.这就是Bupivacaine.这就是Bupivacaína.在水泥水泥中.泥是指一种水泥.这是一个 Elución Elución.化 化 化 化利多卡因 (Lidocaine) 是一种药物.利多卡因 (Lidocaína) 是一种可怕的药物.更多相关视频
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