增加的温度波动会通过肠道微生物群加剧肌肉缩
Ya Liu1, Yifan Guo1, Zheyu Liu1
1Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China.
Nature communications
|June 13, 2023
概括
较高的日间温度范围与肉症的患病率相关. 温度波动加速肌肉缩,通过改变肠道微生物群和增加氨基酸,损害性能.
科学领域:
- 环境健康 环境健康
- 老年学是一门学科.
- 微生物学 微生物学
背景情况:
- 较大的温度差异会给健康带来风险.
- 标志着肌肉损失的萨尔科佩尼亚是一种常见的与年龄有关的疾病.
- 温度波动对萨尔科佩尼亚的影响仍未得到充分研究.
研究的目的:
- 为了研究日间温度范围和人类肉类的患病率之间的相关性.
- 探索波动温度暴露对小鼠肌肉功能和肠道微生物群的影响.
- 阐明关联温度波动,微生物群变化和肌肉功能障碍的潜在机制.
主要方法:
- 昼间温度范围与肉症患病率之间的相关性分析.
- 实验性暴露中年雄性小鼠的温度波动 (10-25°C).
- 16S rRNA测序以分析肠道微生物群的组成.
- 微生物群移植实验和体外测试以评估线粒体功能和线粒体衰变.
主要成果:
- 在较高的白天温度范围和较高的肉类的患病率之间观察到正相关性.
- 在小鼠中,波动的温度暴露加速了肌肉缩,降低了运动性能.
- 他们发现了肠道微生物组合的显著变化,包括增加的Parabacteroides distasonis和Duncaniella dubosii,以及减少的Candidatus Amulumruptor,Roseburia和Eubacterium.
- 从暴露于波动温度的小鼠移植的微生物群复制了不良的肌肉效应.
- 改变的微生物群导致循环氨基酸的增加,通过抑制线粒细胞衰变,损害了线粒体功能.
- 欧细菌补充剂减轻了肌肉缩和功能障碍.
结论:
- 温度波动会对肌肉功能和性能产生不利影响.
- 肠道微生物群的改变在调节温度波动对肌肉健康的不良影响方面发挥着至关重要的作用.
- 由微生物群变化引起的氨基酸增加有助于线粒体功能障碍和肌肉缩.
- 针对肠道微生物群,特别是用Eubacterium,为温度诱导的肌肉功能障碍提供了潜在的治疗策略.
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