长期COVID的自然史在全国范围内,人口队列研究研究
Claire E Hastie1, David J Lowe1,2, Andrew McAuley3,4
1School of Health and Wellbeing, University of Glasgow G12 8TB, Glasgow, UK.
Nature communications
|June 13, 2023
概括
苏格兰长期COVID研究 (Long-CISS) 发现,许多人在感染SARS-CoV-2后会出现持续的症状. 这项研究突出了长期COVID的特定症状,如咳和听力问题,需要进一步调查.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 关于长期COVID的自然历史的研究有限.
- 之前的研究缺乏对照组,阻碍了疾病进展与其他原因的区分.
- 了解长期COVID的发展轨迹对于公共卫生管理至关重要.
研究的目的:
- 为了研究长期COVID的自然历史,使用大量的基于人口的队列.
- 为了比较SARS-CoV-2感染个体的健康结果与匹配的未感染的对照.
- 为了确定特定的症状及其在感染后18个月的进展.
主要方法:
- 苏格兰长期COVID研究 (Long-CISS) 使用了苏格兰范围内的一般人口队列.
- 实验室确认的SARS-CoV-2病例与PCR阴性对照进行了匹配.
- 连续的,自行填写的在线问卷评估了6,12和18个月后的健康状况.
主要成果:
- 35%的有症状的SARS-CoV-2感染报告不完全/没有恢复;12%改善,12%恶化.
- 71.5% (6个月) 和70.7% (12个月) 的感染者报告了持续的症状,而对照人群的53.5%和56.5%相比.
- 虽然味觉/嗅觉变化和混乱状况有所改善,但晚发性咳和听力问题更有可能发生在感染后.
结论:
- 长期COVID显著影响了大量受感染的个体,具有不同的恢复轨迹.
- 持续咳和听力问题等特定症状成为长期COVID的关键指标.
- 这项研究强调了对比组对于了解长期COVID的持续影响的重要性.
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