基因预测咖啡和茶的消费和内动脉瘤的风险
Zhizhong Zhang1, Mengmeng Wang2, Shuai Yuan3
1Department of Neurology, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
European journal of clinical nutrition
|June 13, 2023
概括
咖啡消费可能会增加内动脉瘤 (IA) 和相关出血的风险. 限制咖啡摄入量是建议的,对于高风险的个人IA.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 流行病学 流行病学
背景情况:
- 观察性研究表明咖啡/茶与内动脉瘤 (IA) 风险之间存在联系,但研究结果不一致.
- 门德尔随机化用于调查因果关系,解决观察数据的局限性.
研究的目的:
- 确定基因预测的咖啡和茶的消费是否会对内动脉瘤 (IA) 和其亚型的风险产生因果影响.
- 为了澄清之前的观察性研究中报告的不一致的关联.
主要方法:
- 利用来自大型全基因组关联研究 (GWAS) 的咖啡和茶饮用遗传变异 (多达349,376名受试者).
- 使用来自大型GWAS (79,429名受试者,包括7495例) 的IA总结级数据.
- 进行了门德尔的随机化分析和灵敏度分析,以评估因果关系并排除类.
主要成果:
- 基因预测的咖啡消费与任何IA (OR=1.42) 和动脉瘤下arachnoid出血 (SAH) (OR=1.51) 的风险增加有显著关联.
- 在基因预测的咖啡消费和未被破坏的IA之间没有发现显著的关联.
- 基因预测的茶饮量与IA或其亚型的风险无关.
结论:
- 这项研究提供了证据,支持咖啡消费与IA和相关出血风险增加之间的因果关系.
- 建议建议在被确定为IA和相关出血高风险的人群中限制咖啡摄入量.
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