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轮班工作与2型糖尿病的风险增加和RBP4水平升高有关:来自OHSPIW队列研究的横截面分析

Li Wang^1,2, Qi Ma², BinBin Fang²

¹Departments of Public Health, Xinjiang Medical University, Urumqi, 830011, China.

BMC public health

|June 13, 2023

概括

轮班工作显著增加了2型糖尿病 (T2DM) 的风险,并提高了视网醇结合蛋白4 (RBP4) 的水平. 监测RBP4可能有助于在轮班工人中早期发现T2DM.

科学领域:

职业健康职业健康职业健康
内分泌学在内分泌学.
时间生物学时间生物学

背景情况:

轮班工作破坏昼夜节律,可能增加慢性疾病的风险.
轮班工作的全球流行需要了解其对健康的影响.
生理,行为和心理社会路径都与轮班工作相关的健康问题有关.

研究的目的:

调查轮班工作和2型糖尿病 (T2DM) 之间的联系.
评估轮班工作对视网醇结合蛋白4 (RBP4) 水平的影响.
探索RBP4作为轮班工人T2DM的潜在生物标志物.

主要方法:

1499名油田工人的多阶段分层集群采样 (OHSPIW队列).
数据收集包括关于轮班工作,睡眠质量和T2DM状态的问卷.
分析包括基平方测试,t测试,逻辑回归和等离子体RBP4水平的线性混合模型.

主要成果:

轮班劳动者 (6.56%) 的T2DM患病率高于日间劳动者 (4.21%),即使经过对混因素进行调整 (OR=1.91) 后也是如此.
轮班工作者报告睡眠质量较差 (PSQI得分).
在轮班工作者和T2DM患者中观察到较高的RBP4水平,轮班工作独立地与较高的RBP4相关 (9.51μg/mL增加).

结论:

轮班工作与增加T2DM风险和更高的RBP4水平有关.
RBP4升高与轮班工作和T2DM状态有关.
在职业轮班工作人口中,RBP4监测可能有助于早期发现T2DM.

关键词:

石油工人石油工人石油工人雷丁醇结合蛋白4 是一个结合蛋白.轮班工作轮班工作睡眠质量睡眠质量 2 型糖尿病 2 型糖尿病

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