血清粘膜细胞因子的激增与1型糖尿病风险儿童的血清转化相关
Leonard C Harrison1,2, Esther Bandala-Sanchez1,2, Helena Oakey3
1Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Journal of diabetes investigation
|June 14, 2023
概括
在患1型糖尿病高风险的儿童中,在自身抗体发育的时期,特定细胞因子的暂时上升表明肠道感染可能会触发小岛自身免疫. 这一发现支持了1型糖尿病的环境原因.
科学领域:
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
- 病毒学 病毒学
背景情况:
- 1型糖尿病 (T1D) 源于遗传敏感儿童的小岛自身免疫,可能由肠道病毒等环境因素引发.
- 胰腺小岛抗原的自身抗体是早期标记物,可以识别患T1D高风险的儿童.
研究的目的:
- 调查遗传风险儿童中肠道病理的证据,这些儿童开发了小岛自身抗体 (血清转化).
- 测量从出生开始跟踪的儿童血清中的粘膜相关细胞因子,以确定T1D的潜在环境驱动因素.
主要方法:
- 在岛屿自身免疫的环境决定因素 (ENDIA) 研究中从出生开始进行长度血清采集.
- 血清转化儿童与血清负对照对性别,年龄和样本可用性的匹配.
- 使用Luminex xMap技术量化血清细胞因子.
主要成果:
- 在8名血清转化儿童中,有7名儿童在血清转化期间出现了粘膜相关细胞因子 (IL-21,IL-22,IL-25,IL-10) 和Th17相关细胞因子 (IL-17F,IL-23) 的过渡性峰值.
- 在这些儿童中,也观察到IL-33,IFN-γ和IL-4的水平增加.
- 在匹配的血清阴性对照组或未匹配的血清阴性队列中没有检测到这种细胞因子变化.
结论:
- 粘膜相关细胞因子的暂时系统性增加发生在患T1D风险儿童血清转换的时间左右.
- 这种细胞因子激增支持了粘膜感染的假设,例如肠道病毒,可能会启动小岛自身免疫.
- 研究结果表明,一种潜在的环境触发因素可能导致1型糖尿病的发展.
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