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局部抗生素预测适当的抗生素选择前列腺活检预防

Elizabeth Rourke¹, Steven Madsen¹, Andrea Yunes¹

¹University of Texas Health San Antonio and South Texas Veterans Health Care, San Antonio, Texas.

Urology practice

|June 14, 2023

概括

局部抗生素图准确地反映了大肠杆菌的基诺耐药性,支持其在前列腺活检之前用于向抗生素选择. 这有助于改善抗生素管理和患者的治疗结果.

科学领域:

传染性疾病传染性疾病
泌尿器科泌尿器科泌尿器科泌尿器科
临床微生物学临床微生物学

背景情况:

跨直肠前列腺活检带有感染并发症的风险.
抗生素预防是标准的,但抗药性增加需要精确的局部抗生素图.
评估局部耐药性模式可以确保有效的抗生素增强.

研究的目的:

为了评估南德克萨斯州退伍军人医疗保健系统 (STVHCS) 当地抗生素图的准确性.
为了确定抗生素图表是否反映了诺基诺隆耐药性大肠杆菌的耐药性模式.
为了验证抗生素图的实用性,指导抗生素预防在跨直肠前列腺活检之前.

主要方法:

来自接受过直肠前列腺活检的患者的直肠拭子培养的回顾性分析 (2016年1月 - 2017年9月).
鉴定耐西的埃舍里希亚大肠杆菌分离物.
观察到的耐药性概况与2016年STVHCS抗生素图谱数据的比较.

主要成果:

在队列中对西普罗夫洛克萨的敏感度为80%,而在STVHCS抗生素图中为65% (p <0.001).
在队列 (88%) 和抗生素组 (90%) 之间,对珍塔米辛的敏感性相似.
在安培/苏尔巴克坦敏感度上有显著差异 (32%对57%,p=0.019);4%的抗西普洛素的大肠杆菌是ESBL生产者.

结论:

对于抗西普罗素耐药的大肠杆菌的局部抗生素检测耐药性模式在很大程度上与STVHCS抗生素检测结果一致.
局部抗生素图是实施有针对性的抗生素策略的可靠工具.
这支持使用局部抗生素图片来增强诺基诺在跨直肠前列腺活检中的预防作用.

关键词:

活组织活检药物耐药性耐药性药物耐药性诺基诺的化.微生物敏感性测试试验针头针头是一个针头.前列腺前列腺前列腺

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