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阿根廷的真菌学诊断能力和治疗可访问性的景观

Fernando Riera^1,2, Juan Pablo Caeiro^2,3, Oliver A Cornely^4,5,6,7

¹Division of Infectious Diseases, Sanatorio Allende, Córdoba, Argentina.

Medical mycology

|June 14, 2023

概括

对侵袭性真菌感染的诊断工具和抗真菌治疗方法的获取在阿根廷各地各不相同. 虽然大多数医院都有真菌学部门,但像PCR这样的先进诊断不太常见,影响了患者的护理.

科学领域:

医学真菌学医学真菌学
传染性疾病传染性疾病
公共卫生公共卫生

背景情况:

在阿根廷,侵入性真菌感染 (IFI) 对免疫功能低下的人和患有呼吸道疾病的人构成重大风险.
尽管普遍获得医疗保健,但IFI的诊断和治疗资源的可用性和质量在全国范围内仍然很大程度上没有特征.

研究的目的:

评估阿根廷医疗保健设施中IFI诊断工具和抗真菌剂的现状.
确定在全国范围内获取IFI管理必需资源的潜在差异.

主要方法:

在2022年6月至8月期间进行了一项调查,联系了阿根廷所有23个省份和布宜诺斯艾利斯的传染病临床医生.
收集的数据包括医院特征,患者人口统计,诊断方法的可用性 (组织病理学,自动化方法,银河,MALDI-TOF-MS,PCR),敏感性测试和抗真菌药物获取.
分析了30个反应,以评估FI的诊断和治疗能力.

主要成果:

大多数受访机构 (77%) 是政府机构,其中83%有真菌学部门. 组织病理学是广泛可用的 (93%),而自动化方法和银河曼南测试在57%中存在.
53%的人报告获得MALDI-TOF-MS (通常通过参考实验室),20%的人报告PCR. 在63%的实验室中可以进行敏感性测试.
可纳是普遍可用的,其次是安福特素B脱氧酸盐 (83%) 和伊特拉可纳 (80%). 60%的患者可以在48小时内获得所需的抗真菌药物,如果没有现场储存.
它们包括Candida spp.,Cryptococcus spp.,Aspergillus spp.以及Histoplasma spp.等. 是最经常报告的病原体.

结论:

虽然在阿根廷研究中心的诊断和管理访问方面没有发现显著差异,但仍有改进的余地.
促进意识和资源可用性的国家举措可以加强阿根廷各地侵入性真菌感染的综合管理.

关键词:

阿根廷阿根廷阿根廷阿根廷阿根廷.抗真菌剂是一种抗真菌剂.抗原是一种抗原.文化文化文化文化诊断能力诊断能力的能力.显微镜显微镜是指使用显微镜.分子测试分子测试试验菌类学菌类学是指菌类学.血清学血清学是一门学科.

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