用重定向方法进行治疗管理:在COVID-19爆发期间的一个
Soumik Chaudhury1, Paranjeet Kaur1,2, Deepali Gupta1
1School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi G.T. Road, Phagwara, 144411, Punjab, India.
Current molecular medicine
|June 14, 2023
概括
由SARS-CoV-2引起的COVID-19大流行影响了全球健康. 本综述总结了管理这种动物性传染病爆发的重新设计的策略,强调社会距离和自我护理以及疫苗和治疗.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 由SARS-CoV-2引起的COVID-19流行病导致了广泛的脆弱性和死亡率.
- 病毒的传播动态涉及病毒尖峰RBD和宿主ACE2蛋白之间的相互作用.
- SARS-CoV-2在遗传学上与蝙蝠冠状病毒有关,潜在的中间宿主包括各种哺乳动物和灵长类动物.
研究的目的:
- 审查和总结全球关于管理COVID-19动物传染病爆发方法的研究.
- 突出重新设计的方法来控制社区传播.
主要方法:
- 关于COVID-19管理的科学研究和研究工作的文献综述.
- 对病毒相互作用和宿主受体结合的基因组研究的分析.
- 汇编了疫情控制的拟议和采用的方法.
主要成果:
- 基因组研究揭示了SARS-CoV-2与宿主ACE2相互作用的潜在亲和力变化.
- 识别病毒传播的潜在动物库和中间宿主.
- 强调非药物干预措施,如社交距离和自我护理作为主要控制措施.
结论:
- 有效管理COVID-19大流行需要一个多方面的方法.
- 重新设计的战略,包括公共卫生措施和治疗干预措施,至关重要.
- 对病毒起源,传播和控制方法的持续研究是必不可少的.
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