基于intravoxel不连贯运动和扩散曲解成像的放射学模型,用于预测软组织肉瘤的组织病理学等级和Ki-67表达水平
Yi-Feng Zhu1, Yu-Shi Li1, Yu Zhang2
1Department of Radiology, The Second Hospital, Dalian Medical University, Dalian, PR China.
Acta radiologica (Stockholm, Sweden : 1987)
|June 14, 2023
概括
这项研究表明,使用intravoxel不连贯运动 (IVIM) 和扩散曲解成像 (DKI) MRI的放射学模型可以准确预测软组织肉瘤 (STS) 等级和Ki-67水平. 这些先进的成像技术为STS评估提供了有希望的非侵入性工具.
科学领域:
- 放射学和成像科学 放射学和成像科学
- 瘤学和癌症研究研究
- 医学物理和生物医学工程
背景情况:
- 准确的组织病理学分类和Ki-67表达水平评估对于管理软组织肉瘤 (STSs) 至关重要.
- 目前的方法通常需要侵入性程序,突出了对非侵入性预测工具的需求.
研究的目的:
- 评估使用intravoxel不连贯运动 (IVIM) 和扩散曲解成像 (DKI) MRI参数的放射学模型的可行性.
- 在STS中预测基因病理学等级和Ki-67表达水平的非侵入性方法.
主要方法:
- 一组42名患有STS的患者接受了IVIM和DKIMRI.
- 放射学特征从显微扩散系数 (ADC),D,D*,f和平均度 (MK) 参数图中提取.
- 支持矢量机 (SVM) 模型被训练并验证以预测等级和Ki-67水平,使用AUC和F1-score评估性能.
主要成果:
- D-SVM模型在预测基因病理学等级方面表现强,在验证队列中达到0.88的AUC.
- MK-SVM模型在预测Ki-67表达水平方面表现最好,在验证队列中AUC为0.83.
- 报告了特定的敏感性,特异性和F1分数,用于低级和高级的等级和Ki-67表达.
结论:
- 开发的放射学分类器,集成IVIM和DKI参数,显示出预测STS病理等级的巨大潜力.
- 该模型还有效预测STS中的Ki-67表达水平,提供了有价值的非侵入性评估工具.
相关概念视频
01:30Radiological Investigation II: MRI and Ventilation Perfusion Scan
156
Description
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...
156
01:13Radiological Investigation III: Pulmonary Angiogram and PET Scan
117
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
117
01:17Assessment of Diffusion and Perfusion
1.0K
Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this...
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this...
1.0K