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在阿金氨酸压素受体1A (AVPR1A) 多态性和不平等厌恶之间存在关联
Hiroki Tanaka1, Kuniyuki Nishina2, Qiulu Shou3
1Brain Science Institute, Tamagawa University, Tokyo, 194-8610, Japan.
Proceedings. Biological sciences
|June 14, 2023
概括
氨酸血管压素受体1A (AVPR1A) 基因的遗传变异与有利的不平等厌恶有关. 这项研究探讨了人们对不公平结果的反应的遗传基础.
科学领域:
- 神经科学是一个神经科学.
- 行为遗传学 行为遗传学
- 社会心理学 社会心理学
背景情况:
- 不公平厌恶,人类社会行为的一个关键方面,已经在大脑功能方面进行了广泛的研究.
- 然而,影响个人差异不平等厌恶的遗传因素在很大程度上仍未被探索.
研究的目的:
- 研究与社会行为 (OXTR,AVPR1A,OPRM1) 相关的三种基因中的遗传多态化与不平等厌恶的个人差异之间的关联.
- 为了确定特定的基因型是否与有利的不平等厌恶 (AIA) 或不利的不平等厌恶 (DIA) 相相关.
主要方法:
- 参与者在不同的日子里完成了五个经济游戏实验.
- 用行为反应来通过贝叶斯估计计算AIA和DIA.
- 对氧化素受体 (OXTR rs53576),阿尔金因血管压素受体1A (AVPR1A RS3) 和阿片类受体mu 1 (OPRM1 rs1799971) 中的多态性进行了基因定型.
主要成果:
- 在AVPR1A RS3基因多态和AIA之间发现了显著的关联.
- 与SL或LL基因型相比,具有AVPR1A RS3的SS基因型的参与者表现出更高的AIA.
- 在研究的多态体 (OXTR rs53576,OPRM1 rs1799971) 和DIA或AIA之间没有发现显著的关联.
结论:
- 氨酸血管压素受体1A (AVPR1A) 基因在有利的不平等厌恶中发挥作用,特别是当个人收益超过其他人的时候.
- 这些发现有助于理解社会决策和不平等厌恶的遗传基础.
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