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早期开始的干净间歇性导管可能会降低神经性膀患者骨髓髓瘤细胞度缺陷的患病率和严重性:一项回顾性队列研究
Mohsen Ebrahimnejad1, Seyyed Mohammad Ghahestani2
1Fellow of pediatric urology, Department of pediatric urology, Tehran University of Medical Sciences, Children Medical Center Hospital, Tehran, Iran. mrhamed2009@gmail.com.
Urology journal
|June 14, 2023
概括
早期清洁间歇性导管治疗 (CIC) 在患有骨髓髓髓瘤细胞的儿童有助于通过减少尿度缺陷来保持功能. 这种管理策略在神经性膀患者中比晚发性CIC更有效.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 儿科脏病学 儿科脏病学
- 发育儿科 发育儿科
背景情况:
- 脊柱裂最严重的形式 - - 骨髓髓瘤结核病 - - 带来了终身的泌尿器科挑战.
- 尿度缺陷是常见的,但在骨髓瘤中没有研究过的后果.
- 有效管理神经性膀对于长期患者健康和公共卫生资源至关重要.
研究的目的:
- 追溯评估早期干净间歇性导管治疗 (CIC) 对骨髓瘤细胞瘤患者尿度缺陷的影响.
- 为了比较早期 (<2年) 和晚期 (≥2年) CIC开始者之间的尿度缺陷的严重程度.
- 评估CIC时间对功能保存的长期影响.
主要方法:
- 一项为期10年的回顾性队列研究,涉及130名神经性膀的骨髓髓瘤病患者.
- 用于患者选择的便利抽样方法.
- 早期和晚期CIC发病组之间的多尿症指数比率 (PIR) 和夜间多尿症指数 (NPI) 的比较.
主要成果:
- 与晚发性CIC (≥2年) 患者相比,接受早期发病CIC (<2年) 的患者表现出明显较低的PIR和NPI值.
- 较低的PIR和NPI表明尿路度能力更好,脏损伤风险降低.
- 在随访期间没有报告任何不良事件,这表明早期CIC的安全性.
结论:
- 早期发病的CIC比晚期发病的CIC更有效地保护脏尿度能力,在骨髓髓髓瘤细胞瘤患者.
- 在两岁之前启动CIC是管理神经性膀的有益策略.
- 这一发现支持CIC的早期实施,以减轻儿科脊柱裂的泌尿道并发症.
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