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Updated: Jul 26, 2025

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
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使用怀孕生理学基础的药物动力学模型量化母胎比和羊水度的塞特拉林

David Lartey1,2, Danielle Jateng1,2, Miao Li3

  • 1Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.

British journal of clinical pharmacology
|June 14, 2023
PubMed
概括

基于生理学上的药理动力学 (PBPK) 建模准确地预测了胎儿在怀孕期间接触到塞特拉林的情况. 这种PBPK模型可以指导母亲的塞特拉林剂量调整,以平衡治疗效益并最大限度地降低胎儿风险.

关键词:
PBPKK PBPK 的意思是什么意思抑郁 抑郁症 抑郁症 抑郁症 是一种毒品运输商 毒品运输商怀孕 怀孕 怀孕 怀孕 怀孕这是一种p-g糖蛋白蛋白.

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