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持久性有机污染物与芬兰普通人口样本中的肝病有关

Konsta Hakkarainen¹, Panu Rantakokko², Jani Koponen²

¹Varkaus Regional Hospital, Varkaus, Finland.

Liver international : official journal of the International Association for the Study of the Liver

|June 14, 2023

概括

持久性有机污染物 (POP) 与肝脏损伤有关. 这项研究发现,包括有机农药和PCB在内的POP与肝病生物标志物有关,并增加患肝病的风险.

科学领域:

环境健康环境健康
肝病学肝病学是一种肝病学.
毒理学毒理学毒理学

背景情况:

持久性有机污染物 (POP) 对人类健康构成风险.
新出现的证据表明,POPs与肝脏疾病之间存在联系,但人口数据有限.
了解POPs对肝脏健康的影响对于公共卫生倡议至关重要.

研究的目的:

调查POPs和肝病生物标志物之间的关联.
在基于人口的队列中检查POPs和肝病发病率之间的关系.
确定可能导致肝损伤和疾病进展的特定POPs.

主要方法:

在FINRISK 2007对POPs的调查中分析了2789名成年人的血清样本.
测量标准肝试验和动态阿斯巴酸氨基转移酶-阿兰酸氨基转移酶比率 (dAAR) 作为肝功能生物标志物.
使用线性回归来分析生物标志物协会和使用Cox回归来分析发生性肝病的统计分析.

主要成果:

有机化农药 (OCP),多化双 (PCB) 和高化基物质与肝损伤生物标志物显示出显著的积极关联.
这些关联在肥胖或非酒精性脂肪肝疾病患者中更为明显.
OCP,PCB和 perfluoro-octanoic acid与dAAR有关,这是严重肝脏结果的预测因素,OCP和PCB与发生性肝脏疾病的增加有关.

结论:

几种POP与肝损伤标志物和发生性肝病积极相关.
环境毒素,包括特定的POPs,是慢性肝病的重要风险因素.
需要进一步的研究和公共卫生策略来减轻POP暴露及其与肝脏相关的健康影响.

关键词:

环境污染物环境污染物肝脏功能障碍肝脏功能障碍非酒精性脂肪性肝病是非酒精性脂肪性肝病.持久性有机污染物是一种持久性有机污染物.

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