果提取物对脂质特征的影响:一个结合的体外和人体研究
Maria Pierdomenico1, Arrigo F G Cicero2, Maddalena Veronesi2
1Division of Health Protection Technologies, ENEA-Italian National Agency for New Technologies, Energy and Sustainable Economic Development, Rome, Italy.
Phytotherapy research : PTR
|June 14, 2023
概括
来自果的BrumexTM有效降低胆固醇和甘油三,通过激活AMPK. 临床试验证实了它对高胆固醇贫血患者的脂质样本和肝酶的益处.
科学领域:
- 营养药和功能性食品 营养药和功能性食品
- 心血管健康 心血管健康
- 代谢综合征是代谢综合征的一种.
背景情况:
- 升高的胆固醇和甘油三是心血管疾病的重要危险因素.
- 自然化合物越来越多地被研究,以了解它们在管理脂质配置文件方面的潜力.
- 在临床前研究中,类百加提取物对代谢健康益处有希望.
研究的目的:
- 为了研究BrumexTM的降脂效果,一个果的提取物.
- 阐明 BrumexTM 低脂性作用背后的分子机制.
- 通过人类临床试验验证体外发现.
主要方法:
- 在HepG2细胞中进行临床前评估,以评估细胞毒性和对脂质合成途径的影响.
- 在体外分析AMP激活蛋白激酶 (AMPK) 酸化和与脂质代谢相关的基因表达.
- 这是一项双盲,安慰剂控制,随机的临床试验,在50名中度高胆固醇贫血患者中进行了12周的临床试验.
主要成果:
- 布鲁梅克斯TM在HepG2细胞中没有显示出高达2000微克/毫升的细胞毒性.
- 它通过AMPK激活显著降低了HepG2细胞中的细胞内胆固醇和甘油三.
- 与安慰剂相比,临床试验显示总胆固醇,LDL-C,非HDL-C,甘油三,ApoB,FPG和肝酶 (GOT,GPT,gGT) 的显著降低.
结论:
- 布鲁梅克斯TM表现出显著的低脂和肝脏保护作用.
- 提取物通过AMPK激活和关键脂原基因调节来调节脂质代谢.
- 布鲁梅克斯 (BrumexTM) 是一种有前途的天然成分,可用于治疗脱脂症并改善肝脏健康.
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