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COVID-19患者的肝功能异常及其与年龄和性别的关联:一个跨部门研究
H Karim Abdul-Husseein1, K Akram Al-Akkam2, M Karim Abdul-Husseein3
1Department of Clinical Pharmacy, College of Pharmacy, University of Babylon, Babylon, Iraq.
Archives of Razi Institute
|June 14, 2023
概括
COVID-19 感染可以导致肝脏功能障碍. 这项研究在肝脏异常方面没有发现与年龄相关的差异,但男性的肝功能问题发生率明显更高,特别是AST和ALT水平.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 临床生物化学 临床生物化学
背景情况:
- 肝功能障碍是2019年新冠肺炎 (COVID-19) 患者的已知的并发症.
- 了解COVID-19,肝功能和人口因素之间的关系对于患者管理至关重要.
研究的目的:
- 为了调查COVID-19患者肝功能异常的患病率.
- 检查这些异常与患者年龄和性别之间的关联.
主要方法:
- 通过实时聚合酶链反应确认的167名COVID-19患者进行了一项横截面研究.
- 分析和比较不同年龄组和男性和女性之间的肝功能测试.
- 统计分析包括奇平方和曼-惠特尼U测试,具有P < 0.05.05的显著性水平.
主要成果:
- 总体而言,49.1%的COVID-19患者表现出异常的肝脏检测.
- 不同年龄组之间没有观察到肝检测异常的显著差异 (P=0.784).
- 肝功能异常在男性 (68.3%) 与女性 (37.5%) (P=0.001) 相比,在男性 (68.3%) 中显著更为普遍,AST和ALT水平有显著差异.
结论:
- COVID-19患者在不同年龄组的肝功能异常中没有显著差异.
- 男性COVID-19患者的肝功能障碍发病率较高,特别是与女性相比,血清AST和ALT水平的显著差异证明了这一点.
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