马鲁 (Marrubium persicum) 改善了与小鼠血管生成和炎症相关的生物学参数
K Fekri1, M Sh Mortezaie2,3, N Maleki-Dizaji3
1Department of Paramedicine, Amol School of Paramedical Sciences, Mazandaran University of Medical Sciences, Sari, Iran.
Archives of Razi Institute
|June 14, 2023
概括
马鲁 (Marrubium persicum) 甲醇提取物在小鼠模型中显示出显著的抗炎作用. 这种草药提取物减少了炎症和血管生成,提供了潜在的治疗益处.
科学领域:
- 药理学 药理学是指药理学的学科.
- 自然产品化学 自然产品化学
- 免疫学 免疫学 免疫学
背景情况:
- 林叶科家族,包括马鲁属,以其传统的药用而闻名.
- 马鲁 (Marrubium persicum) 是一种有着在草药中应用历史的物种.
研究的目的:
- 为了研究Marrubium persicum甲醇提取物的抗炎和抗血管生成潜力.
- 评估M.persicum提取物在卡拉基诱导的炎症小鼠模型中的疗效.
主要方法:
- 使用甲醇通过索克斯莱特装置提取M.persicum的上空部分.
- 在小鼠中建立了一个由卡拉基南诱导的炎症的气囊模型.
- 小鼠接受了不同剂量的M.persicum提取物或甲治疗,并评估了炎症标志物和血管生成.
主要成果:
- 梅桃花甲醇提取物在3.5至10毫克/公斤的剂量下显著降低了炎症参数.
- 最佳剂量 (3.5 mg/kg) 显著降低了髓氧化酶 (MPO) 活性,血管生成和血红蛋白水平.
- 提取物证明了对中性粒细胞透的抑制作用.
结论:
- 桃木的甲醇提取物具有显著的抗炎性质.
- 抗炎作用可能归因于抗氧化作用和抑制中性粒细胞透.
- 梅桃花提取物显示出治疗炎症状况和抑制血管生成的潜力.
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