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Updated: Jul 26, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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基于皮拉的宏循环激酶抑制剂的设计和合成,针对BMPR2

Jennifer A Amrhein1,2, Guiqun Wang1,2,3, Benedict-Tilman Berger1,2

  • 1Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe-University, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany.

ACS medicinal chemistry letters
|June 14, 2023
PubMed
概括

研究人员通过修改一种乱交化合物 (1) 开发了一种选择性BMPR2抑制剂 (8a). 这一进步针对II型受体,为肺动脉高血压等疾病提供了新的治疗潜力.

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