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Updated: Jul 26, 2025

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

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N-Aryl Indoles作为一种新型类强大的NaV1.7 抑制剂

Narayan Karanjule1, Noriyuki Hayashi1, Sayaka Suzuki1

  • 1Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.

ACS medicinal chemistry letters
|June 14, 2023
PubMed
概括

研究人员发现了新型的N-烯 indole 化合物,可有效抑制NaV1.7通道. 化合物2e在体内显示出高疗效和优异的药理动力学,代表了一个有前途的治疗候选者.

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